What are the key numbers?
How does it work?
Retatrutide activates three hormone receptors at once: GLP-1, GIP and glucagon. GLP-1 and GIP signal fullness and help regulate blood sugar, while glucagon signalling raises the energy the body uses. In trials this showed as lower appetite and steady weight loss.
What does the research say?
Published studies, strongest evidence first.
- Randomised trial
Phase 3 TRIUMPH-1 trial in 2,339 adults: weight fell about 24-25% over 80 weeks versus 4% on placebo.
N Engl J Med, 2026 · PubMed - Randomised trial
Phase 2 trial in 338 adults with obesity: weight fell up to 24% over 48 weeks versus 2% on placebo.
N Engl J Med, 2023 · PubMed
What does the community report?
Community anecdotes, not scientific evidence.
Some users report substantial, steady weight loss over several months.From r/Peptides · 1 thread
Several people describe quieter food noise and less interest in fast food.From r/Peptides · 1 thread
Some users report losing interest in alcohol and other habitual cravings.
Community reports are not evidence. Side effects recorded in the studies are in the research summary above.
- Substantial weight loss3 threads
- Reduced appetite and food noise2 threads
Discussed on Reddit
What should you know?
- There are randomised trials in people, the strongest kind of evidence.
- For research and education, not medical advice. Talk to a health professional before using any peptide.
Frequently asked questions
What is Retatrutide?
A triple-hormone peptide (GIP, GLP-1 and glucagon receptors) studied for weight and metabolic health in large human trials.
How strong is the evidence for Retatrutide?
There are randomised trials in people, the strongest kind of evidence. This summary covers 2 published studies, each labelled by study type.
Is Retatrutide registered with BPOM?
No. Retatrutide from Continue is a research-grade compound, not a medicine, and is not registered with BPOM.
Where can I buy Retatrutide with a COA in Indonesia?
Continue sells research-grade Retatrutide with a COA for every batch, shipped cold across Indonesia.
