Tesamorelin

A growth hormone-releasing hormone (GHRH) analogue studied for visceral belly fat, liver fat and cognition in human trials.

Randomised trial3 studies2 min readUpdated 2 Oct 2026

What are the key numbers?

−15.2%visceral (deep belly) fat at 26 weeksRandomised trial, 412 adults with HIV and abdominal fat; placebo +5.0%Randomised trialPubMed
−37%liver fat at 12 months versus placebo, relative to baselineRandomised trial, 61 adults with HIV and fatty liverRandomised trialPubMed
−7.4%body-fat percentage after 20 weeksRandomised trial, 152 adults aged 55–87, some with mild cognitive impairmentRandomised trialPubMed

How does it work?

Tesamorelin is a lab-made version of growth-hormone-releasing hormone (GHRH). It prompts the pituitary gland to release more of the body’s own growth hormone, which in studies reduced deep belly (visceral) fat. In the US it is approved for one specific use: excess belly fat in people with HIV.

What does the research say?

Published studies, strongest evidence first.

  • Randomised trial

    In 61 people with HIV and fatty liver, one year of tesamorelin lowered liver fat versus placebo.

    Lancet HIV, 2019 · PubMed
  • Randomised trial

    20 weeks of tesamorelin modestly improved executive function in 152 older adults, with or without mild cognitive impairment.

    Arch Neurol, 2012 · PubMed
  • Randomised trial

    In adults with HIV and abdominal fat, 26 weeks of tesamorelin reduced visceral fat by about 15%.

    N Engl J Med, 2007 · PubMed

What does the community report?

Community anecdotes, not scientific evidence.

  • Some users report less stubborn belly fat after several weeks.From r/Peptides, r/Retatrutide, r/Biohackers · 3 threads

  • Several users describe deeper, more restful sleep.From r/Retatrutide · 1 thread

  • Some users notice better recovery and firmer-feeling muscle alongside training.From r/Peptides, r/Biohackers · 2 threads

Community reports are not evidence. Side effects recorded in the studies are in the research summary above.

Discussed on Reddit

What should you know?

  • There are randomised trials in people, the strongest kind of evidence.
  • For research and education, not medical advice. Talk to a health professional before using any peptide.

Frequently asked questions

What is Tesamorelin?

A growth hormone-releasing hormone (GHRH) analogue studied for visceral belly fat, liver fat and cognition in human trials.

How strong is the evidence for Tesamorelin?

There are randomised trials in people, the strongest kind of evidence. This summary covers 3 published studies, each labelled by study type.

Is Tesamorelin registered with BPOM?

No. Tesamorelin from Continue is a research-grade compound, not a medicine, and is not registered with BPOM.

Where can I buy Tesamorelin with a COA in Indonesia?

Continue sells research-grade Tesamorelin with a COA for every batch, shipped cold across Indonesia.

Tesamorelin
Available at ContinueTesamorelinFrom Rp 2.200.000 Rp 2.750.000
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